Air Force General Hospital PLA

Fetal hypoxia causes oocyte oxidative stress damage via the Sirt3/Sod2 pathway and can be alleviated by nicotinamide mononucleotide.

Environmental hypoxia exerts detrimental effects on the reproductive capabilities of both humans and animals. A fetal hypoxia model was established in which fetal mice were kept in a high-plateau hypoxic setting from embryonic day (E) 0 to 16.5. In our previous research, we found...

Reconstruction of traumatic proximal femoral bone defects with personalized 3D-printed porous Ti-6Al-4V prosthesis: a case report and literature review

Abstract Background Reconstruction of critical-sized proximal femoral defects caused by high-energy trauma remains a formidable orthopedic challenge due to compromised mechanical stability, anatomical complexity, and limited biological integration capacity. Traditional methods (a...

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Pathological cartilage calcification represents a pivotal pathological alteration in osteoarthritis (OA), yet its underlying mechanisms remain poorly understood. Exosomes are involved in facilitating calcification, and their biogenesis may be linked to autophagy disruption. Howev...

Aerobic exercise inhibits lung adenocarcinoma invasion dependent on the superior cervical ganglion

To elucidate possible neural and molecular pathway mechanisms underlying the suppression of aerobic exercise in lung adenocarcinoma (LUAD) invasion. Sympathetic nerve distribution was visualized via immunofluorescent staining in human tissue microarrays (TMAs) and mouse lung spec...

Mannose Ameliorates Radiation-Induced Intestinal Injury in Mice via Preventing Mitochondrial Dysfunction

Aims: Radiation-induced intestinal injury (RIII) severely compromises the quality of life in patients undergoing abdominal/pelvic radiotherapy and may necessitate treatment discontinuation. To date, there is no approved agent for the prevention or treatment of RIII. This study ai...