AHEPA University Hospital

High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention: How to Choose the Optimal Antithrombotic Therapy, Its Duration and the Right Stent; A Comprehensive Review of the Current Literature and Proposed Treatment Algorithms

High bleeding risk (HBR) patients represent a significant proportion of those who undergo percutaneous coronary interventions (PCI). The accurate diagnosis of the HBR population is essential because they suffer significantly higher rates of mortality and bleeding compared with no...

Treatment restrictions after acute stroke across nine European countries and their association with 90-day mortality: a post hoc analysis of the PRECIOUS randomised controlled trial

Background In patients with acute stroke, early withholding or withdrawal of life-sustaining therapies is associated with an increased risk of death. We used practice variation across nine European countries to assess whether this relation may be causal. Methods We performed a po...

Testing a Prespecified Matrix Transcriptional Programme in Myeloid Cells from Proliferative Vitreoretinopathy Membranes: A Donor-Aware Computational Single-Cell Study

Whether myeloid cells in proliferative vitreoretinopathy (PVR) membranes directly transcribe a coherent extracellular matrix (ECM) programme remains uncertain. We tested a prespecified seven-gene programme in a discovery cohort (GSE294329; five PVR donors) and an independent epir...

Parental stress, coping, and depressive symptoms among parents of preterm infants hospitalised in a Greek neonatal intensive care unit: A cross-sectional study

Purpose To examine NICU-related parental stress, coping strategies, and depressive symptoms in a single-centre, cross-sectional study of parents of preterm infants in a tertiary NICU in Greece. Principal results Thirty-four parents from 18 families participated. NICU-related stre...

Longitudinal Trajectories of Physical and Mental Health-Related Quality of Life Following Psychobiotic Supplementation in Gastrointestinal Oncology Patients: A Post Hoc Analysis of the ProDeCa Study

Background/Objectives: Patients undergoing surgery followed by adjuvant chemotherapy for gastrointestinal cancer frequently experience impaired health-related quality of life (HR-QoL). This post hoc analysis of the ProDeCa randomized trial investigated whether psychobiotic treatm...

Mycoplasma pneumoniae–associated reactive infectious mucocutaneous eruption (RIME) confirmed by multiplex PCR: a case-based review

Abstract Reactive infectious mucocutaneous eruption (RIME) is a para-infectious syndrome characterised by prominent mucositis with limited cutaneous involvement, typically following a respiratory illness. Diagnostic uncertainty is common because RIME may mimic erythema multiforme...

The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry

Abstract Aims The right ventricle (RV) is a major determinant of outcome in pulmonary arterial hypertension (PAH), but its assessment has not been completely incorporated in the risk of mortality scores. We therefore evaluated the added value of echocardiography of the RV to risk...

Left and Right Atrial Strain Across the Heart Failure Continuum: Multifaceted Markers of Subclinical Mechanical Dysfunction and Haemodynamic Burden

Heart failure (HF) is increasingly recognized as a progressive syndrome that begins long before patients develop clinical signs or symptoms, during which conventional echocardiographic parameters may fail to detect early myocardial impairment. Atrial strain imaging by speckle-tra...

Cause of death in a contemporary cohort of patients with pulmonary arterial hypertension

Abstract Background In pulmonary arterial hypertension (PAH), contemporary risk tools primarily estimate all-cause mortality, offering limited insight into what patients die from. Aims We aimed to characterize causes of death across baseline risk strata and to examine baseline fa...

Oral Pemphigus in Children and Adolescents: A Narrative Review of Published Case Reports

Background: Pemphigus is a rare group of autoimmune blistering diseases characterized by autoantibody-mediated loss of keratinocyte adhesion, resulting in intraepithelial blister formation involving the skin and mucous membranes. Pemphigus Vulgaris (PV) is the most common type of...

Neuroimaging findings of the hypothalamus and pituitary gland in children with growth hormone deficiency: a 25-year single-center retrospective study

Abstract Purpose Growth hormone deficiency (GHD) is a cause of short stature in childhood. Central nervous system imaging, including hypothalamic-pituitary magnetic resonance imaging (MRI) is important for the diagnostic investigation of these patients. The aim of this descriptiv...

Multimodal Correlates of Longitudinal Functional Decline in Behavioral Variant Frontotemporal Dementia (bvFTD)

Background and Objectives: Functional decline is a major determinant of disability, caregiver burden, and loss of independence in behavioral variant frontotemporal dementia (bvFTD). Although bvFTD is characterized by early and rapidly progressive deterioration in everyday functio...