Agios Pharmaceuticals (United States)

Tebapivat: Pharmacokinetic Properties in Preclinical Species and Pharmacodynamic Responses Associated With Pyruvate Kinase Activation in Wild‐Type Mice

ABSTRACT The investigation of pyruvate kinase activating drugs is expanding into previously untested diseases as the benefits of increasing glycolytic flux within pyruvate kinase‐expressing tissues emerges. Recently, we reported the discovery of allosteric activator tebapivat, an...