Aga Khan University Nairobi

Immunohistochemistry vs Molecular Breast Cancer Subtyping Among African Populations

Importance Breast cancer subtyping based on immunohistochemistry (IHC) guides systemic therapy where gene expression profiling assays are unavailable, yet its validity against molecular reference standards remains poorly characterized in African populations, where laboratory infr...

Machine learning models to predict low birth weight in the Kenyan Coast

Low birth weight (LBW, < 2500 g) is associated with poor outcomes across multiple domains of child development. Predicting high-risk pregnancies for LBW will therefore enable timely intervention. We aimed to develop and internally validate machine learning models to predict LBW i...

Biochar and compost application synergistically enhance soil microbial activity in coastal savanna Acrisol

The use of organic fertilizers such as compost and biochar have received much research attention but their potential synergistic effects on soil biological properties have not been sufficiently investigated. This study investigated the effects of combined application of empty fru...

A qualitative study of the communication and information needs of parents of preterm Infants in a tertiary health facility in Northeast Nigeria

While the need for hospitalisation in preterm infants is a well-recognized source of stress and anxiety for most parents, the communication and informational needs of parents during this period remain vastly understudied in sub-Saharan Africa. This study aimed to investigate the...

Effects of heat exposure on self-reported heat strain symptoms among pregnant and postpartum women in South Africa

Abstract Heat exposure can harm pregnant and postpartum women, yet heat strain symptoms in this population remain underexplored. This study implemented a novel mobile application and assessed the environmental context of five self-reported heat strain symptoms: skin rashes, sleep...

Impact of LLM assistance on physician decision-making: a multi-country randomized controlled trial

Abstract Disparities in the quality of healthcare persist globally, with poor-quality care contributing significantly to preventable mortality, particularly in low- and middle-income countries. While digital technologies, including generative artificial intelligence (AI), hold pr...

Utility of Face2Gene’s DeepGestalt and D-Score applications in paediatric neurodevelopmental disorders in South Africa

Abstract Face2Gene is a clinical tool that leverages facial features to aid genetic diagnosis. The DeepGestalt application suggests potential diagnoses based on facial similarity, while the D-Score evaluates likelihood of an individual having dysmorphic features suggestive of a p...

Reducing the diagnostic and treatment gap for priority mental, neurological and substance misuse disorders in primary care in rural Kenya: Results of a stepped wedge cluster randomized trial from the EPINA study

ABSTRACTBackground: In resource-limited settings, care for mental, neurological and substance misuse (MNS) disorders has been integrated into primary healthcare facilities (PHC) by training primary health workers (PHW) on the use of the mental health Gap Action Program Interventi...

A longitudinal multi‑proxy geospatial classification of peri‑urban transitions across community health units in coastal Kenya

<title>Abstract</title> <bold>Background:</bold> Urbanization is spatially heterogeneous in many sub-Saharan African settings. This complicates community health planning when rural and peri-urban labels are applied informally or updated inconsistently. We assessed whether multipl...