Aga Khan University Hospital

Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation

Background The effect of timely appropriate antibiotics in multidrug-resistant Gram-negative bacteria (MDR-GNB) bloodstream infections (BSIs) remains uncertain. Robust evidence is needed to inform diagnostic and treatment strategies, especially across settings with high antimicro...

Immature Teratoma With Rhabdomyosarcomatous Transformation or Overgrowth: The First Reported Case at a Cervicovaginal Site

Background Extragonadal immature teratomas are rare, accounting for 1%-2% of all germ cell tumors. Rhabdomyosarcomatous transformation arising within an immature teratoma at a cervicovaginal site has not been previously reported. The absence of standardized treatment guidelines f...

Shared patterns of human milk composition link mammary gland function to infant growth

The mammary gland produces nutrient-rich human milk (HM), yet how mammary functional state shapes HM composition and infant outcomes remains poorly understood. We used HM multi-omics - metabolomics, proteomics, micronutrients, macronutrients, and HM oligosaccharides - across 1,54...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Changes in the knowledge, attitudes, and practices of school teachers following an educational intervention in Skardu: a quasi-experimental study

To evaluate within-participant changes in knowledge, attitude, and practice (KAP) among school teachers following a structured educational intervention on children’s eye health in Skardu District, Gilgit-Baltistan (GB), Pakistan. This single-group pre–post quasi-experimental stud...

Bridging the health literacy gap: Women and community stakeholders’ perspectives on maternal and child health communication in peri-urban Karachi, Pakistan

Abstract Health literacy significantly influences health outcomes, particularly in Low-and Middle-Income Countries. Communication of maternal and child heath messages occurs via text messages, phone calls, television, newspaper articles, and home visits. An exploratory qualitativ...

Deep learning super-resolution of paediatric ultra-low-field MRI without paired high-field scans

ABSTRACT Brain magnetic resonance imaging (MRI) is essential for diagnosis and neurodevelopmental research, but the high cost and infrastructure demands of high-field MRI limit its use to high-income settings. Ultra-low-field MRI scanners offer a more affordable and energy-effici...