Affiliated Hospital of Zunyi Medical College

Preclinical Evaluation of 89Zr-Labeled Anti-Nectin-4 Antibody for Enhanced PET Imaging in Bladder Urothelial Carcinoma

Abstract This study evaluated the preclinical performance of a novel 89Zr-labeled anti-Nectin-4 monoclonal antibody, [89Zr]Zr-DFO-MW282, for PET imaging of bladder urothelial carcinoma (BUC). [89Zr]Zr-DFO-MW282 was prepared via p-isothiocyanatobenzyl-desferrioxamine (p-NCS-Bn-DFO...

Integrated Multi-Omics Profiling of Thymoma Identifies Subtype-Specific Remodeling and Myasthenia Gravis-Associated Targets

Abstract Thymoma is a rare thymic epithelial tumor strongly associated with myasthenia gravis (MG), yet the tumor intrinsic molecular states underlying this link remain unclear. Here, we profiled paired thymoma and distant nontumorous thymic tissues using untargeted metabolomics,...

Integrated murine and human transcriptomics prioritizes a multicellular mitochondrial signature associated with immune and parenchymal features in NAFLD/MASLD

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), historically termed nonalcoholic fatty liver disease (NAFLD), involves metabolic dysregulation, mitochondrial stress, and immune remodeling. However, disease-associated multicellular transcriptional progra...

Bardoxolone methyl exerts an inhibitory effect on respiratory syncytial virus infection by downregulating IL-6 via the IKKβ/NF-κB signaling pathway

ABSTRACT Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in infants, older adults, and immunocompromised individuals, but therapeutic options for active infection remain limited. Interleukin-6 (IL-6) contributes to RSV replication and RSV-induce...

Integrated multi-omics analysis identifies AKR1B15 and SLC4A10 as prognostic candidate citrullination-related genes associated with metabolic and immune programs in hepatocellular carcinoma

Protein citrullination has been increasingly implicated in tumor progression and immune regulation, but the prognostic and cellular characteristics of citrullination-related genes (CRGs) in hepatocellular carcinoma (HCC) remain incompletely understood. We integrated bulk transcri...

Association between serum lactate trajectories and short-term mortality in pediatric acute kidney injury patients

OBJECTIVE: Acute kidney injury (AKI) is a life-threatening condition in children. Serum lactate is a critical indicator of oxygen metabolism and tissue hypoperfusion. This study investigated the association between early dynamic lactate trajectories during pediatric intensive car...

First-line immune checkpoint inhibitors versus chemotherapy in delaying quality of life deterioration in advanced NSCLC: a systematic review and meta-analysis

Backgroud: Immune checkpoint inhibitors (ICIs) have transformed first-line treatment for advanced non–small-cell lung cancer (aNSCLC). While overall survival(OS) remains the primary endpoint, health-related quality of life (HRQoL) is a key patient-centered outcome. Time to deteri...

The role of C-reactive protein to lymphocyte ratio and sleep duration in heart failure: exploring the mechanistic interplay and clinical implications

Heart failure (HF) is a progressive disease with complex pathogenesis involving inflammation, immune dysfunction, and metabolic abnormalities. Although C-reactive protein (CRP) is an established HF marker, the CRP-to-lymphocyte ratio (CLR) integrates inflammatory and immune respo...

Sitravatinib combined with osimertinib overcomes acquired osimertinib resistance in NSCLC by targeting AXL and the PI3K/AKT/GSK3β signaling pathway

The emergence of acquired resistance to osimertinib has emerged as a severe plight in the clinical management of patients with advanced harboring epidermal growth factor receptor mutations non-small cell lung (NSCLC). We comprehensively evaluated sitravatinib, an emerging multita...

FGF12, a FoxO1-downregulated gene, promotes the survival of trophoblast cells in gestational diabetes mellitus: a preliminary study

OBJECTIVES: Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with adverse maternal and fetal outcomes. Although the prevalence of GDM is high, the molecular mechanisms involved in GDM-related placental dysfunction remain poorly understood. This st...