Affiliated Hospital of Youjiang Medical University for Nationalities

Intravenous verapamil as salvage therapy for reperfusion-related refractory electrical storm following acute inferior myocardial infarction: a case report

Abstract Background Electrical storm following acute myocardial infarction is associated with high mortality. A subset of these cases is refractory to conventional therapies, including amiodarone, beta-blockers, and defibrillation. The calcium channel blocker verapamil is typical...

A Recyclable Coconut‐Shell‐Carbon‐Based Photocatalyst for Robust Antimicrobial Activity and Enhanced Wound Repair

ABSTRACT Acinetobacter baumannii ( A. baumannii ) is a notorious nosocomial pathogen for its extensive drug resistance and adaptability. This study developed a novel heterojunction photocatalyst (PC), PTQ10‐SY1, supported on coconut shell charcoal (CSC), a carbon material derived...

Global Paid and Unpaid Productivity Losses Due to Gastrointestinal Cancer Mortality

OBJECTIVES: Gastrointestinal (GI) cancers contribute substantially to premature mortality, yet their full economic burden, including unpaid work, remains underquantified. We aimed to estimate global productivity losses attributable to GI cancer mortality, considering paid and unp...

Ovarian tumor domain-containing protein 1 deficiency attenuates metabolic dysfunction-associated steatotic liver disease by promoting the ubiquitination of HSP90α in hepatocytes

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, yet approved pharmacotherapies remain limited. The ovarian tumor domain-containing protein 1 (OTUD1) has been implicated in metabolic regulation, but i...

miR‐7641: A Novel Diagnostic Biomarker for Rheumatoid Arthritis That Exerts Protective Effects by Targeting TNFSF10

ABSTRACT Rheumatoid arthritis (RA) is closely associated with genetic factors, but there is still a lack of ideal biomarkers for its early diagnosis and precise intervention. To investigate the diagnostic value and synovial cell function of miR‐7641 in RA, and its mechanistic lin...

Association between lipid accumulation product index (LAP index) and coronary artery disease risk

Coronary artery disease (CAD) is a highly prevalent condition that predominantly affects obese individuals and those with metabolic abnormalities. The lipid accumulation product (LAP), combining waist circumference (WC) and triglyceride (TG) measurements, provides a clinically re...

Unraveling the bidirectional interplay of the gut microbiota with chemotherapy and radiotherapy in colorectal cancer: from pathogenesis to probiotic interventions

Colorectal cancer remains a leading cause of cancer-related mortality worldwide. While chemotherapy and radiotherapy serve as a cornerstone of treatment, their clinical efficacy is frequently compromised by therapeutic resistance and gastrointestinal toxicity. Accumulating eviden...

Homoharringtonine suppresses cervical cancer progression through modulation of the EGFR/PI3K/AKT/mTOR signaling pathway

Homoharringtonine (HHT), a natural alkaloid approved for treating hematological malignancies, has shown potential activity against solid tumors, but its role in cervical cancer remains unexplored. This study investigates the anti-cervical cancer effects of HHT and its impact on t...

circBIRC6 regulates cisplatin resistance of choroidal melanoma via positively modulating ERK by sponging miR-503-3p

Abstract Background/AimscircRNA plays a key regulatory role in various human tumors. This study was carried out to investigate the molecular mechanism of circBIRC6 in the regulation of choroidal melanoma cisplatin (DDP) resistance. MethodsThe expression of circBIRC6 in choroidal...

Higher eGFRdiff is associated with increased risk of rapid kidney function decline in hypertensive individuals

Abstract Background Hypertensive nephropathy is the second contributing factor to end-stage renal disease, while the relationship between the difference between estimated glomerular filtration rates (eGFRdiff) and rapid kidney function decline (RKFD) in hypertensive patients rema...

Electrochemiluminescence-enhanced mesoporous composite enabling sensitive deoxynivalenol detection and nano-delivery of a ROCK inhibitor for spinal cord injury

Spinal cord injury (SCI) creates a highly inhibitory microenvironment that severely limits axonal regeneration and reduces the therapeutic efficacy of the Rho-associated protein kinase (ROCK) inhibitor Y-27632. To address this challenge, a natural-product-functionalized coordinat...

PSMD11 promotes hepatocellular carcinoma progression by reprogramming lipid metabolism via SREBP1/2 and PPAR-γ

Abstract Dysregulation of the ubiquitin-proteasome system (UPS) plays a pivotal role in tumor progression. PSMD11, a non-ATPase regulatory subunit of the 26S proteasome, has been implicated as an oncogenic factor in several cancer types; however, its precise biological function a...

Mechanism of Nitidine chloride against esophageal squamous carcinoma based on network pharmacology, molecular docking, and experimental validation

Nitidine chloride (NC) is a natural alkaloid that inhibits tumor proliferation and induces apoptosis in tumor cells. However, the role of NC in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to explore the effects of NC on the proliferation, apoptosis, and mi...

TRIM28 regulate G2/M transition via histone modification and DNA damage repair during mouse oocyte meiosis

TRIM28, a member of the tripartite motif (TRIM) family, functions as a transcriptional coregulator involved in maintaining genome stability during mitosis. However, transcriptional activity is barely detectable during oocyte meiotic maturation. In this study, we explored the role...

Identification and validation of RNA-binding protein-associated biomarkers in esophageal cancer

Abstract Background Esophageal cancer (ESCA) is highly prevalent globally, but the role of RNA-binding proteins (RBPs) in it remains unclear. Methods ESCA datasets were analyzed to identify differentially expressed genes (DEGs). Candidates were derived by intersecting DEGs with R...

A multifunctional chitosan-based nanozyme (1-CS@vitexin) with enzyme-mimicking and photothermal synergistic effects for targeted liver fibrosis therapy

Liver fibrosis, driven by excessive extracellular matrix deposition and hepatic stellate cell (HSC) activation, remains a major clinical challenge. Here, we developed a multifunctional chitosan-based nanozyme ( 1-CS@vitexin ) by integrating the natural flavonoid vitexin into a ni...

Bioactive prenylated acylphloroglucinols from Hypericum scabrum

Ten prenylated acylphloroglucinols were obtained from the whole herb of Hypericum scabrum, four of which (1–4) are undescribed compounds. Structural identification was accomplished by extensive spectral analyses including HRESIMS, 1D and 2D NMR, DP4+ combined with 13C NMR quantum...

Adherence to the DASH diet moderates the association between sedentary time and the risk of obstructive sleep apnea in a hypertensive rural Chinese population: a cross-sectional study

Obstructive sleep apnea (OSA) and hypertension form a vicious cycle. While sedentary behavior is an emerging risk factor for OSA, and the dietary approaches to stop hypertension (DASH) diet offers cardiometabolic benefits, their interplay in non-obese hypertensive patients remain...