Affiliated Hospital of Youjiang Medical University for Nationalities

Electrochemiluminescence-enhanced mesoporous composite enabling sensitive deoxynivalenol detection and nano-delivery of a ROCK inhibitor for spinal cord injury

Spinal cord injury (SCI) creates a highly inhibitory microenvironment that severely limits axonal regeneration and reduces the therapeutic efficacy of the Rho-associated protein kinase (ROCK) inhibitor Y-27632. To address this challenge, a natural-product-functionalized coordinat...

PSMD11 promotes hepatocellular carcinoma progression by reprogramming lipid metabolism via SREBP1/2 and PPAR-γ

Abstract Dysregulation of the ubiquitin-proteasome system (UPS) plays a pivotal role in tumor progression. PSMD11, a non-ATPase regulatory subunit of the 26S proteasome, has been implicated as an oncogenic factor in several cancer types; however, its precise biological function a...

Mechanism of Nitidine chloride against esophageal squamous carcinoma based on network pharmacology, molecular docking, and experimental validation

Nitidine chloride (NC) is a natural alkaloid that inhibits tumor proliferation and induces apoptosis in tumor cells. However, the role of NC in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to explore the effects of NC on the proliferation, apoptosis, and mi...

TRIM28 regulate G2/M transition via histone modification and DNA damage repair during mouse oocyte meiosis

TRIM28, a member of the tripartite motif (TRIM) family, functions as a transcriptional coregulator involved in maintaining genome stability during mitosis. However, transcriptional activity is barely detectable during oocyte meiotic maturation. In this study, we explored the role...

Identification and validation of RNA-binding protein-associated biomarkers in esophageal cancer

Abstract Background Esophageal cancer (ESCA) is highly prevalent globally, but the role of RNA-binding proteins (RBPs) in it remains unclear. Methods ESCA datasets were analyzed to identify differentially expressed genes (DEGs). Candidates were derived by intersecting DEGs with R...

Bioactive prenylated acylphloroglucinols from Hypericum scabrum

Ten prenylated acylphloroglucinols were obtained from the whole herb of Hypericum scabrum, four of which (1–4) are undescribed compounds. Structural identification was accomplished by extensive spectral analyses including HRESIMS, 1D and 2D NMR, DP4+ combined with 13C NMR quantum...

A multifunctional chitosan-based nanozyme (1-CS@vitexin) with enzyme-mimicking and photothermal synergistic effects for targeted liver fibrosis therapy

Liver fibrosis, driven by excessive extracellular matrix deposition and hepatic stellate cell (HSC) activation, remains a major clinical challenge. Here, we developed a multifunctional chitosan-based nanozyme ( 1-CS@vitexin ) by integrating the natural flavonoid vitexin into a ni...

Adherence to the DASH diet moderates the association between sedentary time and the risk of obstructive sleep apnea in a hypertensive rural Chinese population: a cross-sectional study

Obstructive sleep apnea (OSA) and hypertension form a vicious cycle. While sedentary behavior is an emerging risk factor for OSA, and the dietary approaches to stop hypertension (DASH) diet offers cardiometabolic benefits, their interplay in non-obese hypertensive patients remain...