Affiliated Hospital of Taishan Medical University

Comparison of quantitative CT parameters acquired via the CT spine bone quantification system between L1 cortical and cancellous bone for predicting severity in male patients with chronic obstructive pulmonary disease: a retrospective study

Until present, data on the association between cortical bone changes in osteoporosis and severity of the condition of Chronic obstructive pulmonary disease (COPD) patients are lacking. This study aims to explore and compare the value of quantitative parameters of cortical and can...

Three case reports and a literature review of HER-2-overexpressing mammary Paget’s disease combined with invasive breast cancer

To investigate the clinicopathological characteristics, treatment, and short-term outcomes of human epidermal growth factor receptor 2 (HER-2)-overexpressing mammary Paget’s disease (MPD) combined with invasive ductal carcinoma (IDC), with an emphasis on the high proportion of HE...

Squamous cell carcinoma arising from ovarian mature cystic teratoma with concurrent cervical high-risk HPV infection and low-grade squamous intraepithelial lesion: a case report

Malignant transformation of ovarian mature cystic teratoma (MCT) is uncommon, with squamous cell carcinoma (SCC) being the predominant type. Its pathogenesis remains poorly understood, and the potential role of human papillomavirus (HPV) infection is controversial. A 58-year-old...

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes...

Intranasal delivery of BDNF-enriched small extracellular vesicles ameliorates cognitive impairment and Alzheimer’s disease-like pathology in APP/PS1 mice

Alzheimer’s disease (AD), the leading cause of dementia, still lacks broadly effective disease-modifying therapies. Here, we engineered brain-derived neurotrophic factor (BDNF)-enriched small extracellular vesicles (BDNF-sEVs) from human induced pluripotent stem cell-derived mese...

Molecular and clinical characterization of human adenovirus in hospitalized pediatric respiratory infections: a five-year study

Abstract Background Human adenovirus (HAdV) is a major pathogen of responsible for respiratory tract infections (RTIs) in children in China. This study analyzed clinical data from hospitalized pediatric HAdV infections over a five-year period to characterize the epidemiology, cli...

Hostile microenvironment-driven oxygenator hydrogel with spatiotemporally feedback regulated hif-1α for accelerating diabetic wound healing

Diabetic wounds remain notoriously intractable due to a hostile microenvironment characterized by hyperglycemia, hypoxia, and oxidative stress. However, existing therapies often lack the ability to autonomously and sustainably remodel this pathological niche. Herein, a smart nano...

A retrospective study on clinical and survival differences of head and neck versus other second primary malignancies in nasopharyngeal carcinoma survivors

Abstract Background Nasopharyngeal carcinoma (NPC) survivors face elevated risks of second primary malignancies (SPM); however, disparities between head and neck (HN-SPM) and non-head and neck (non-HN-SPM) are incompletely characterized. Methods This retrospective study analyzed...

Development and validation of a preoperative interpretable machine learning model for predicting myocardial injury following lung cancer surgery

Myocardial injury after non-cardiac surgery (MINS) is a common complication following lung cancer surgery and is associated with adverse prognostic outcomes. Preoperative cardiac risk assessment is essential for optimizing perioperative management and improving patient outcomes....