Affiliated Hospital of Nantong University

A quantitative and visual detection probe based on isothermal nucleic acid amplification coupled with CRISPR/Cas12a system (INACS) for miR155 detection

MicroRNAs (miRNAs) have emerged as ideal biomarkers for early clinical diagnosis. Achieving the accurate detection of miRNAs plays a critical role for assuring its implementation in their clinical applications. In this study, we developed a dual-signal amplified ultrasensitive fl...

Associations of maternal mood on the outcome of childbirth: a latent profile analysis

It is important to recognize that childbirth and the transition to the maternal role constitute a profound identity reconstruction, involving both the physical experience of labor and the psychological adaptation to motherhood, during which many women experience unstable and inte...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Extraction-reasoning gaps in open-source LLM grading of liver pathology reports

Large language models (LLMs) may reduce the manual effort required to convert narrative pathology reports into structured research data, but it remains unclear whether their performance reflects extraction of explicit diagnostic labels or genuine histopathological reasoning. We e...

Integrated Transcriptomic and Machine-Learning Analyses Identify Shared Na+ Overload-Related Gene Signatures in Inflammatory Bowel Disease and Ankylosing Spondylitis

Background: Ankylosing Spondylitis (AS) and inflammatory bowel disease (IBD) exhibit substantial pathophysiological overlap, including dysregulated innate immunity, barrier dysfunction, and Th17-mediated inflammation. However, whether Na+ overload-related genes (NRGs) exhibit sha...

Development of machine learning models for predicting delirium in elderly patients after thoracic surgeries

Postoperative delirium (POD) is a frequent neurological complication following anesthesia and surgery, which is associated with increased comorbidities and mortality. The current study developed and internally validated a machine learning model for predicting POD in elderly patie...