Affiliated Hospital of Nantong University

Molecular subclassification of MGMT-unmethylated high-grade glioma identifies divergent tumor states and therapeutic vulnerabilities

MGMT-unmethylated high-grade glioma (HGG) is associated with poor response to temozolomide and limited therapeutic options. However, substantial molecular heterogeneity exists within this clinically defined subgroup and remains insufficiently characterized. Transcriptomic and cli...

The total serum N-glycome landscape of hematological malignancies

A holistic and dynamic view of the glycomic landscape in hematological malignancies (HMs) remains poorly characterized, hindering clinical the application of glycomics in HMs. We launched a large-scale analysis of multicenter cohorts, combining retrospective (n=1,370) and prospec...

Local verification of ceftriaxone gradient strip MIC testing for Neisseria gonorrhoeae after CLSI 2026 breakpoint changes

from ≤0.25 mg/L to ≤0.12 mg/L, classified 0.25 mg/L as intermediate, and removed ceftriaxone disk diffusion interpretive criteria. We conducted a single-center, retrospective method-comparison study of 111 consecutive, nonduplicate, culture-confirmed isolates with paired ceftriax...

ENOPH1 orchestrates KRASG12D/G13D-driven glycolytic reprogramming and colorectal cancer progression through modulating the TGF-β/SMAD pathway

Oncogenic KRAS mutations (G12D/G13D) drive metabolic reprogramming in colorectal cancer (CRC), yet targetable downstream effectors remain poorly defined. Here, we identify enolase-phosphatase 1 (ENOPH1) as an essential transducer directly upregulated by the KRAS–MEK–ERK axis. ENO...

A neutrophil-mimetic nanoplatform integrating lipid mediators and immunoregulation for myocardial repair

Myocardial infarction (MI) triggers excessive oxidative stress and uncontrolled inflammation, which impede cardiac repair. Conventional anti-inflammatory or antioxidant therapies often fail to restore immune homeostasis or promote tissue regeneration effectively. Hence, developin...

Development and application of simple self-locking surgical tubing tourniquet for laparoscopic Pringle maneuver

Pringle maneuver is a critical technique for controlling hepatic inflow and minimizing blood loss during laparoscopic liver resection. However, traditional methods of performing this maneuver can be cumbersome in laparoscopic settings. This study introduces a simple self-locking...

Network meta-analysis of intrathyroidal injection of combined dexamethasone with lidocaine for subacute thyroiditis

Background: Intrathyroidal injection of dexamethasone (Dex) alone (monotherapy) or combined Dex with lidocaine (combination therapy) has been used for treating subacute thyroiditis (SAT). We performed this study to simultaneously determine whether intrathyroidal injection of Dex...

Axillary nerve risk mapping and arm-length-based prediction in percutaneous proximal humeral fracture fixation

Detailed knowledge of axillary nerve anatomy and its relationship to a proximal humeral locking plate is important for reducing iatrogenic nerve injury during percutaneous minimally invasive plate osteosynthesis (MIPO) for proximal humeral fractures. Twelve adult upper-limb cadav...

Association between pericoronary CT fat attenuation index and coronary artery spasm

Fat attenuation index (FAI) is currently used in research on coronary atherosclerotic heart disease, but there are no reports on FAI applications in coronary artery spasm (CAS). In this study, we explored the association between pericoronary FAI and CAS. Patients who had chest pa...

Noncanonical function of Claudin-1 mitigates lethal endoplasmic reticulum stress to drive prostate cancer lineage plasticity and chemoresistance

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mech...

Context-dependent functional diversity of dorsomedial posterior parietal neurons revealed by single-unit fMRI mapping during naturalistic viewing

Abstract The dorsomedial posterior parietal cortex (dmPPC) plays an important role in episodic processing by integrating sensory, cognitive, and motor information across distributed brain systems. However, how individual dmPPC neurons participate in large-scale functional organiz...

DPP9 modulates RPA1 stability and temozolomide sensitivity through RFWD3 Nuclear localization in glioma

Temozolomide resistance is a major barrier to effective glioma treatment and is frequently associated with enhanced DNA damage repair capacity. Although DPP9 has been linked to tumor development in several malignancies, whether it contributes to glioma therapeutic resistance has...

Interdependencies among factors related to participation in smart home-based elderly care platforms in China: an exploratory social network analysis

Despite increasing policy investment in smart home-based elderly care platforms, participation among older adults and care institutions remains limited. Existing studies have primarily examined participation-related factors from either the demand or supply side, but have paid lim...

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

ABSTRACT Chimeric antigen receptor (CAR)‐engineered cell therapies are being extended from hematological malignancies to autoimmune, inflammatory, and fibrotic diseases, although the maturity of evidence differs markedly among platforms and indications. Early clinical evidence fr...

Trajectories of Kinesiophobia and Influencing Factors in Patients With Acute Myocardial Infarction

It is widely acknowledged that kinesiophobia is prevalent among patients suffering from acute myocardial infarction (AMI). Although heightened kinesiophobia significantly predicts adverse outcomes, it should be recognized that this fear is dynamic and typically evolves during the...

Tissue engineering scaffolds for the spinal cord: recent advances and future prospects

Spinal cord tissue engineering scaffolds represent a highly promising option for the treatment and repair of spinal cord injury (SCI). They have a wide range of potential applications and, as essential biomaterial carriers, can restore the multifunctional microenvironment. Since...

A quantitative and visual detection probe based on isothermal nucleic acid amplification coupled with CRISPR/Cas12a system (INACS) for miR155 detection

MicroRNAs (miRNAs) have emerged as ideal biomarkers for early clinical diagnosis. Achieving the accurate detection of miRNAs plays a critical role for assuring its implementation in their clinical applications. In this study, we developed a dual-signal amplified ultrasensitive fl...

Associations of maternal mood on the outcome of childbirth: a latent profile analysis

It is important to recognize that childbirth and the transition to the maternal role constitute a profound identity reconstruction, involving both the physical experience of labor and the psychological adaptation to motherhood, during which many women experience unstable and inte...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Extraction-reasoning gaps in open-source LLM grading of liver pathology reports

Large language models (LLMs) may reduce the manual effort required to convert narrative pathology reports into structured research data, but it remains unclear whether their performance reflects extraction of explicit diagnostic labels or genuine histopathological reasoning. We e...