Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine

SHP2 accelerated acute liver injury via modulating TGFβ1/EZH2/BRD4 signaling induced proliferation and fibrosis of HSC

To explore the specific molecular mechanisms by which SHP2 promotes liver injury. Single-cell transcriptomics and bioinformatics analyses were employed for predictive screening. C57BL/6J mice were assigned to normal, model, and model+PHPS1 groups. Liver injury and fibrosis were e...