Affiliated Hospital of Jiangsu University

Number of natural teeth and incident cognitive impairment in older Chinese adults

This study aimed to examine the longitudinal association between baseline number of natural teeth and incident cognitive impairment among older Chinese adults in the Chinese Longitudinal Healthy Longevity Survey and explore whether dietary diversity partially mediated this associ...

Extracellular vesicle-derived circ6853 drives vascular remodeling and serves as a potential biomarker and therapeutic target for gastric cancer

Gastric cancer (GC), a leading global malignancy, urgently requires the discovery of novel diagnostic and therapeutic targets. The roles of extracellular vesicle (EV)- derived circular RNAs (circRNAs) as diagnostic biomarkers and functional regulators, particularly in vascular re...

Suppression of PKM2 by Leonurine Attenuates Alcoholic Hepatitis Through Regulating Glycolytic Reprogramming

Alcoholic hepatitis (AH) is a liver disease caused by long-term heavy drinking. In the early stages, it usually manifests as fatty liver, which can then develop into liver fibrosis and cirrhosis. Kupffer cells are liver resident macrophages and the effect of glycolytic reprogramm...

The total serum N-glycome landscape of hematological malignancies

A holistic and dynamic view of the glycomic landscape in hematological malignancies (HMs) remains poorly characterized, hindering clinical the application of glycomics in HMs. We launched a large-scale analysis of multicenter cohorts, combining retrospective (n=1,370) and prospec...

Machine-learning classification of myocardial infarction and ST/T-change ECG phenotypes across complementary evaluation settings

The primary PTB-XL outcome was an operational ECG phenotype defined by myocardial infarction and/or ST/T-change diagnostic superclass labels, rather than adjudicated active ischemia. Public ECG datasets were harmonized to 10-s, 12-lead, 100-Hz inputs. Patient-disjoint PTB-XL part...

Mitogenome architecture and evolutionary insights in Origanum vulgare: comparative analysis of structural diversity and repeat-mediated recombination

Origanum vulgare is a perennial herb known for its antimicrobial, antioxidant, and anti-inflammatory properties, valued in both traditional medicine and modern phytopharmacology. Despite substantial research on its chemical and pharmacological properties, genomic studies have bee...

Potential therapeutic effects of Lactobacillus on Pancreatic ductal adenocarcinoma through its metabolite Harmaline

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal form of cancer. Recent research has uncovered the role of the gut microbiota in influencing PDAC progression and treatment outcomes. Dysbiosis of gut microbiota in PDAC patients has been shown to negatively...

Cellular crosstalk of fibroblast–myofibroblast transition in intestinal homeostasis and disease

Fibroblasts are central components of the intestinal microenvironment and can acquire a myofibroblast phenotype through fibroblast-to-myofibroblast transition (FMT), a process linked to increased tissue mechanosensitivity and active extracellular matrix (ECM) remodeling. In this...

Sodium L-lactate alleviates DSS-induced colitis through gut microbiota remodeling and Akkermansia enrichment

L-lactate, a byproduct of glycolysis and hypoxia, accumulates in the gut during disease progression and may affect host responses and microbial metabolism. Here, we investigated the protective effect of sodium L-lactate on dextran sulfate sodium (DSS)-induced colitis in mice and...

Exercise snacking as a novel strategy for prevention and intervention of frailty in older adults: a scoping review

As the population ages, frailty among older adults becomes a significant public health challenge. Conventional, long-duration exercise is often unsuited for older adults, whereas “exercise snacking”—a new, bite-sized approach to physical activity—shows great promise. However, mos...

Polygenic risk score analysis for major depressive disorder in a Chinese cohort: single-phenotype and pathway-based approaches

Abstract Background Major depressive disorder (MDD) is a global mental health challenge characterized by high prevalence, disability, and recurrence, with its susceptibility showing substantial polygenic inheritance. Polygenic risk scores (PRS) provide a novel method to explore c...

C5aR1-positive PMN-MDSC-induced angiogenesis limits the efficacy of radiotherapy combined with Anti-PD-1 immunotherapy

Radiotherapy (RT) combined with Anti–PD-1 immunotherapy (RT + Anti-PD-1) offers synergistic potential in the treatment of colorectal cancer (CRC). However, RT + Anti-PD-1 often fails to be effective in some patients with CRC, because a subset of tumors exhibits limited responsive...

Quo vadis? – Visualizing the tropism of tumor-derived cellular nanovesicles

Small extracellular vesicles (sEVs) and nanovesicles (NVs) derived from tumor cells hold great potential for targeted drug delivery due to their inherent tumor-homing properties. This study aimed to comparatively evaluate the physicochemical characteristics, cellular uptake, phar...

A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes

OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...

Deciphering the landscape of human pathogenome in non-typhoidal Salmonella through multidimensional genomics

Non-typhoidal Salmonella (NTS) is a leading foodborne pathogen causing severe gastrointestinal and systemic infections, posing a significant global health burden. This study employed a genomic approach to investigate the functional and distribution characteristics of human pathog...

Association of D-dimer/Lymphocyte ratio with severity in acute pancreatitis: a cross-sectional study

The D-dimer/lymphocyte ratio (DLR) reflects coagulation activation and immune status, but its association with the severity of acute pancreatitis (AP) remains unclear. This study aimed to investigate the relationship between DLR and AP severity. This cross-sectional study include...

Applications and Research Progress of Biomaterials for Treating Infected Bone Defects

Infected bone defects represent a challenging clinical condition that requires simultaneous infection control and bone structure reconstruction. Traditional antibiotic therapy and bone grafting each have inherent limitations. With advances in regenerative medicine and tissue engi...

Association between remnant cholesterol inflammatory index and new-onset stroke in different glycemic metabolic states: insights from the China health and retirement longitudinal study

The remnant cholesterol inflammatory index (RCII) has been proposed as a novel biomarker for lipid dysregulation and inflammation, and has also been suggested as a potential risk factor for diabetes. However, the association between RCII and the incidence of new-onset stroke acro...

Active ingredients and molecular targets of Tripterygium wilfordii against colorectal cancer: network pharmacology, molecular docking, molecular dynamics simulations and in vitro evaluation

Colorectal cancer (CRC) is one of the common malignant tumors of the gastrointestinal tract, encompassing both colon cancer and rectal cancer. This study explores the therapeutic potential of T. wilfordii in CRC through network pharmacology, molecular docking, and in vitro experi...