Affiliated Hospital of Jiangsu University

Deciphering the landscape of human pathogenome in non-typhoidal Salmonella through multidimensional genomics

Non-typhoidal Salmonella (NTS) is a leading foodborne pathogen causing severe gastrointestinal and systemic infections, posing a significant global health burden. This study employed a genomic approach to investigate the functional and distribution characteristics of human pathog...

Association of D-dimer/Lymphocyte ratio with severity in acute pancreatitis: a cross-sectional study

The D-dimer/lymphocyte ratio (DLR) reflects coagulation activation and immune status, but its association with the severity of acute pancreatitis (AP) remains unclear. This study aimed to investigate the relationship between DLR and AP severity. This cross-sectional study include...

Active ingredients and molecular targets of Tripterygium wilfordii against colorectal cancer: network pharmacology, molecular docking, molecular dynamics simulations and in vitro evaluation

Colorectal cancer (CRC) is one of the common malignant tumors of the gastrointestinal tract, encompassing both colon cancer and rectal cancer. This study explores the therapeutic potential of T. wilfordii in CRC through network pharmacology, molecular docking, and in vitro experi...

Association between remnant cholesterol inflammatory index and new-onset stroke in different glycemic metabolic states: insights from the China health and retirement longitudinal study

The remnant cholesterol inflammatory index (RCII) has been proposed as a novel biomarker for lipid dysregulation and inflammation, and has also been suggested as a potential risk factor for diabetes. However, the association between RCII and the incidence of new-onset stroke acro...

Applications and Research Progress of Biomaterials for Treating Infected Bone Defects

Infected bone defects represent a challenging clinical condition that requires simultaneous infection control and bone structure reconstruction. Traditional antibiotic therapy and bone grafting each have inherent limitations. With advances in regenerative medicine and tissue engi...