Affiliated Hospital of Hebei University

Association between in-hospital changes in estimated plasma volume status and worsening renal function in patients with acute heart failure

Worsening renal function (WRF) during treatment for acute heart failure (AHF) has context-dependent clinical implications. Estimated plasma volume status (ePVS), calculated from hematocrit and body weight, may complement decongestion assessment. We evaluated the association betwe...

Robinetin Alleviates Streptozotocin-induced Diabetic Nephropathy in Rats by Mitigating Oxidative Stress and Inhibiting Inflammatory Cascades

Background Diabetic nephropathy is a pivotal cause of kidney morbidity, affecting a major portion of individuals with diabetes and frequently progressing to renal failure requiring dialysis or transplantation. There is a growing need to identify safer therapeutic alternatives, su...

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Perfluorodecanoic acid (PFDA) exposure, through stabilizing HIF-1α to induce VEGF/VEGFR2 autocrine signaling, promotes colorectal cancer cell proliferation

Perfluorodecanoic acid (PFDA) is a persistent organic pollutant widely present in the environment and resistant todegradation. In recent years, due to its extensive use in industrial production and consumer products, PFDA continuously accumulates in organisms and has become a glo...

Circulating miR-106b-5p discriminates acute myocardial infarction patients, predicts disease severity, and regulates H/R-induced cardiomyocyte injury by targeting CDKN1A

The early detection, disease monitoring, and prognosis prediction are of great significance for acute myocardial infarction (AMI). This study focused on miR-106b-5p, evaluating its clinical significance in AMI onset and progression. This study enrolled 147 AMI patients with 123 s...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

The FOXQ1/SSBP2 Regulatory Axis Drives Malignant Progression of Melanoma

ABSTRACT Melanoma is a highly aggressive skin cancer with poor prognosis, often linked to excessive UV exposure. Despite advancements in immunotherapy and targeted treatments, melanoma's invasiveness and metastatic potential remain significant challenges. This study aimed to iden...

Evaluation of the efficacy and safety of first-line therapies for peripheral T-cell lymphoma: a systematic review and network meta-analysis

Objective To compare the efficacy and safety of first-line therapies for peripheral T-cell lymphoma (PTCL) via network meta-analysis. Methods We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials (RCTs) evaluating first-l...

Feasibility analysis of negative pressure wound therapy for odontogenic ascending necrotizing fasciitis: a single-center single-arm retrospective case series

Abstract Background Odontogenic ascending necrotizing fasciitis (ANF) is an extremely rare, rapidly progressive, and destructive craniomaxillofacial necrotizing soft tissue infection. Advanced surgical drainage is essential to improve cure rates, shorten the disease course, and a...

Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer

Background Persistent human papillomavirus (HPV) infection is a key driver in cervical cancer, yet the molecular mechanisms linking HPV to immune escape remain incompletely understood. Methods We integrated single-cell RNA sequencing (scRNA-seq), bulk transcriptome, and clinical...

Association between the time window of rash recurrence and the risk of renal involvement within 6 months in children with immunoglobulin A vasculitis

Renal involvement is a major determinant of long-term outcome in childhood immunoglobulin A vasculitis (IgAV). We examined whether the timing of the initial rash recurrence was associated with renal involvement within 180 days, while accounting for temporal ordering, rash phenoty...

Association of dietary oxidative balance score, dietary inflammatory potential and fractures among adults aged ≥ 40 years in the United States in 1999-2018.

BACKGROUND AND OBJECTIVES: The Dietary Oxidative Balance Score (DOBS) and Dietary Inflammatory Index (DII) reflect dietary oxidative and inflammatory status. This study investigated their associations with the prevalence of wrist, hip, and spine fractures. METHODS AND STUDY DESIG...

Esketamine induces ferroptosis and suppresses immune evasion in lung adenocarcinoma cells via the hsa_circ_0022392/miR-548b-3p/MAP7 axis

Abstract Background Although Esketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used for anesthesia and analgesia and has shown anticancer activity, its effects on lung adenocarcinoma remain unclear. Circular RNAs have been implicated in the development and...