Affiliated Hospital of Hangzhou Normal University

Clinical Evaluation of Bacterial Lysate for Immune Regulation and Exacerbation Reduction in Stable Chronic Obstructive Pulmonary Disease

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and is accompanied by systemic immune dysfunction, and recurrent acute exacerbations are the main determinants of disease progression, hospitalisation and poor prognos...

A Bridge From the Gut: Azithromycin Links to AMPK/SIRT1 Activation, Rectifies Th17/Treg Balance and Alleviates COPD Associated With Gut Microbiota-TMAO Modulation

Background: The intestinal microbial ecosystem has emerged as an important contributor to chronic obstructive pulmonary disease (COPD) pathogenesis. Azithromycin (AZI), a commonly used therapeutic agent for COPD, has antibacterial and anti-inflammatory effects. This study aims to...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitophagy via the myeloid cell leukemia 1 (MCL-1)/light chain 3A...