Affiliated Hospital of Guangdong Medical College Hospital

Comparison of Postoperative Complications and Perioperative Outcomes Between Endoscopic-Assisted and Open Prosthetic Breast Reconstruction: A Retrospective Study

AIM: To compare the incidence of complications within 90 days postoperatively and perioperative outcomes between endoscopic-assisted and open prosthetic breast reconstruction.METHODS: Data from female patients who underwent total mastectomy and prosthetic breast reconstruction fr...

Association of F11 Gene Variants With Cardiovascular Events and Cardiac Function

Background FXI (Factor XI) inhibitors have emerged as a promising antithrombotic strategy. However, a recent study linked decreased FXI levels with increased risk of heart failure (HF) and atrial fibrillation (AF), particularly in older adults. This study aims to investigate the...

Resveratrol Maintains Hippocampal Mitochondrial Function and Inhibits Neuronal Ferroptosis to Improve Diabetes-Associated Cognitive Dysfunction via Sirt1/Shh Signaling

Background Resveratrol has been shown to play a neuroprotective role in diabetic cognitive dysfunction. We determined whether resveratrol improved diabetic cognitive dysfunction through ferroptosis regulation, and explored the potential mechanism. Methods Rats were fed with a hig...

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

BACKGROUND: Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttran...

Pleura organoid transplantation facilitates visceral pleural repair through CD133+ progenitor cell-mediated regeneration

Abstract Persistent pulmonary air leakage following thoracic surgery remains a major clinical challenge. Here we establish murine and human pleura organoids as a novel regenerative therapy. Morphological and functional analyses confirm that these organoids retain mesothelial mark...

The value of combined SATB2 and CDX2 detection in the differential diagnosis of colorectal adenocarcinoma

This study evaluates the diagnostic value of SATB2 and CDX2, used individually and in combination, in the immunohistochemical differential diagnosis of colorectal adenocarcinoma. A retrospective case-control diagnostic accuracy study was conducted, including 122 patients with his...

Identifying potential macrophage polarization-related causal genes in sepsis through multi-omics mendelian randomization analysis and experimental validation

The genetic associations between macrophage polarization-related genes (MPGs) and sepsis remain unclear. This study aimed to identify sepsis-associated MPGs. Based on blood-derived methylation quantitative trait loci (mQTL), expression QTL (eQTL), and protein QTL (pQTL) data for...