Affiliated Eye Hospital of Wenzhou Medical College

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

ABSTRACT Dry eye disease (DED), a chronic disorder affecting nearly half the global population, is perpetuated by oxidative stress, inflammation, and tear film instability. Constrained by short precorneal residence and monotherapy, DED therapies necessitate frequent dosing and po...

Textural features of retina and choroid obtained via machine learning based on OCT image identify early macular degeneration in high myopia

To study a set of textural features based on optical coherence tomography (OCT) images using texture analysis via machine learning to demonstrate their potential for early identification of macular degeneration in high myopia (HM). Two hundred and eighty-eight eyes of 166 partici...

Association between contrast sensitivity and myopia control efficacy

This study compared central visual quality in myopic children wearing spectacles with highly aspherical lenslets (HAL) versus traditional single-vision spectacle lenses (SV) and examined the association between contrast sensitivity and myopia control efficacy. Myopic children age...

MIDAS: A multimodal interview-based framework for depression assessment from clinical interviews

Automated depression assessment from clinical interviews is a challenging intelligent healthcare task because depressive states are reflected not only in verbal responses, but also in acoustic and visual-behavioral cues. Existing multimodal methods have improved prediction perfor...

Outcomes of modified pneumatic retinopexy with transscleral subretinal fluid drainage for primary rhegmatogenous retinal detachment

Abstract Background Primary rhegmatogenous retinal detachment (RRD) occurs when a retinal tear or break causes fluid from inside the eye to seep behind the retina, which pushes it away from the wall of the eye. This can cause permanent vision loss if not treated. Which of three c...

Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework

Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and ex...

Regional Dependence of Corvis ST Biomechanical Parameters on Corneal Material Properties: A Finite Element Study

Background: Corvis ST (CVS) provides dynamic corneal response parameters for biomechanical assessment, but conventional metrics may not uniquely reflect region-specific alterations in corneal material properties. This study investigated how regional changes in corneal material pr...

Orbital apex syndrome caused by imaging-occult sphenoid sinus fungal infection and the necessity of early surgical exploration: a retrospective case series

To characterize a highly occult subtype of sphenoid invasive fungal rhinosinusitis (IFRS) presenting as acute orbital apex syndrome (OAS) without classic invasive imaging signs, and to evaluate the efficacy of early surgical intervention. This retrospective case series evaluated...

3D epigenomic landscape of the human retinal pigment epithelium

The retinal pigment epithelium (RPE) is crucial for visual function, and its dysfunction contributes to retinal diseases such as age-related macular degeneration. Despite the translational potential of iPSC-derived RPE (iPSC-RPE) in cell replacement therapy, the functional visual...