Advanced Centre for Treatment, Research and Education in Cancer

Study protocol for a randomized, double-blind, placebo-controlled clinical trial to assess chemoprotective efficacy of Aqueous standardized extract of Tinospora cordifolia (AsSET) in patients receiving Docetaxel based chemotherapy for advanced / metastatic solid tumors

Introduction Docetaxel is widely used for advanced and metastatic solid tumours, but dose limiting toxicities, particularly haematological adverse events, often lead to treatment delays, dose reductions or discontinuation and impair quality of life. Tinospora cordifolia (Guduchi)...

Gcn5 and mTORC1 mediated regulation of autophagy controls Drosophila blood cell homeostasis

Blood progenitors are regulated by a variety of systemic and nutritional cues from their environment. In the Drosophila lymph gland (LG), the Posterior Signalling Center (PSC) acts as a stem cell niche striking a balance between progenitors and differentiated blood cells. Autopha...

Process Characterization and Determinants of CD3⁺ Cell Yield During Autologous Leukapheresis for CAR-T Cell Manufacturing: A Single-Centre Experience from Western India

Background Chimeric Antigen Receptor T-cell ( CAR T-cell) therapy is a promising treatment option for patients with refractory or relapsed B-cell malignancies. The success of this therapy depends on the efficient collection of lymphocytes (CD3 + T cells) through apheresis. This s...

A Qualitative Exploration of Facilitators and Barriers to Control of Hypertension and Type 2 Diabetes Mellitus in Rural Nagpur, Central India

Abstract Background: Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are increasingly prevalent in rural India, yet disease control remains suboptimal due to a confluence of socio-cultural, behavioral, and systemic challenges. Understanding community-perceived facilitators...

Concurrent ETV6::ABL1 and BCR::ABL1 in a rare case of chronic myeloid leukemia: a paradox of imatinib resistance and indolent clinical course

Abstract Chronic myeloid leukaemia (CML) is characterized by the presence of BCR::ABL1 showing favorable response to imatinib therapy. Complex rearrangements in CML are indicative of clonal evolution and often associated with disease progression and poor response to therapy. Cyto...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...