Academic Center for Dentistry Amsterdam

Rapid purity and charge-variant analysis of bispecific antibodies using microfluidic capillary electrophoresis-mass spectrometry

Bispecific antibody (BsAb) therapeutics have the ability to bind two targets simultaneously, which opens up new pathways for disease treatment. BsAbs consist of distinct heavy and light chains that need to be assembled correctly to form the appropriate heterodimer. However, durin...

Noise differentially affects the osteocyte and osteoblast response to fluid shear stress

Stochastic resonance occurs in non-linear systems when the response to a weak periodic input is strengthened by the presence of noise. Whether a noisy mechanical environment can similarly increase the mechanosensitivity of bone cells, thereby amplifying their response to loading,...

Radiological Late Dental Adverse Effects Following Treatment for Paediatric Head and Neck Rhabdomyosarcoma: Results of a Transatlantic Multicentre Cohort Study

ABSTRACT Objectives Rhabdomyosarcoma represents the most common paediatric soft tissue sarcoma, with 40% occurring in the head and neck region. Given that survival rates now reach 80%, minimising late adverse effects, particularly dental developmental complications, has become a...