Academic Center for Dentistry Amsterdam

AI ‐Driven Feedback on Bitewing Radiographic Technique: A Comparative Study of Large Language Models

ABSTRACT Introduction Large language models (LLMs) can enhance learning engagement and accessibility, though their performance in dentistry is inconsistent. Bitewing radiographs are critical for caries detection but prone to diagnostic errors from operator positioning. This study...

A Patient-Specific Digital Twin Model for Haptic-Based Dental Simulation: Development and Pilot Evaluation of Its Static Design

Purpose: Haptic and mixed-reality (MR) simulation technologies are increasingly used in preclinical dental education to support psychomotor skill acquisition and to reduce early patient exposure. This technical feasibility study aimed to develop a patient-specific digital twin pa...

Early‐stage myocardial changes are not aggravated by Western diet or ageing in Mybpc3 c.2373insG heterozygous mice

Abstract Hypertrophic cardiomyopathy (HCM) caused by heterozygous pathogenic gene variants is characterized by highly variable disease phenotypes. Ageing and systemic metabolic disruption are thought to act as additional ‘second hits’ that modulate this genotype–phenotype relatio...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

The Key Factor Toxicity: development and application of a toxic pressure characterization tool for surface and drinking water

The European Water Framework Directive (WFD) aims to ensure a status with sufficient good-quality water to sustain ecosystems and drinking water production. Water quality is, however, affected by complex mixtures of polluting substances, whose combined effects are poorly captured...

Noise differentially affects the osteocyte and osteoblast response to fluid shear stress

Stochastic resonance occurs in non-linear systems when the response to a weak periodic input is strengthened by the presence of noise. Whether a noisy mechanical environment can similarly increase the mechanosensitivity of bone cells, thereby amplifying their response to loading,...

Rapid purity and charge-variant analysis of bispecific antibodies using microfluidic capillary electrophoresis-mass spectrometry

Bispecific antibody (BsAb) therapeutics have the ability to bind two targets simultaneously, which opens up new pathways for disease treatment. BsAbs consist of distinct heavy and light chains that need to be assembled correctly to form the appropriate heterodimer. However, durin...

Radiological Late Dental Adverse Effects Following Treatment for Paediatric Head and Neck Rhabdomyosarcoma: Results of a Transatlantic Multicentre Cohort Study

ABSTRACT Objectives Rhabdomyosarcoma represents the most common paediatric soft tissue sarcoma, with 40% occurring in the head and neck region. Given that survival rates now reach 80%, minimising late adverse effects, particularly dental developmental complications, has become a...