Abu Dhabi Health Services

Establishment of local diagnostic reference levels for mammography: optimizing patient radiation dose within Emirates Health Services

Abstract Background Mammography is a key imaging modality for early breast cancer detection, but it involves exposure to ionizing radiation. This study aimed to establish local Diagnostic Reference Levels (LDRLs) for 2D and 3D mammography within Emirates Health Services (EHS) fac...

Public health workforce reform in Abu Dhabi: a pathway to evidence-based policy and global standards alignment

Reforming the public health workforce in Abu Dhabi and across the United Arab Emirates (UAE) became increasingly urgent during and after the COVID-19 pandemic, alongside wider pressures from evolving public health challenges and health-system transformation. A mixed-methods study...

Use of Vaginal Estrogen in Breast and Gynecologic Cancer Survivors

To review the safety, efficacy, and clinical considerations of vaginal estrogen therapy for the treatment of genitourinary syndrome of menopause (GSM) in patients with a history of breast or gynecologic cancer. This is a narrative review of the current literature and clinical gui...

Immunotherapy-Related Cardiac Arrythmias: Incidence, Pathobiology, Risk Factors and Management

Abstract Purpose of Review Immunotherapies have revolutionized treatment strategies for cancer patients, improving the prognosis in many populations with advanced malignancies. Immune check point inhibitors (ICI) and Chimeric antigen receptor (CAR) T cell therapy are being increa...

Testicular Tissue Cryopreservation in Prepubertal Boys: Current Advances, Clinical Feasibility, and Future Directions—A Comprehensive Literature Review

ABSTRACT Background Prepubertal boys cannot use semen cryopreservation because mature spermatozoa are not yet produced. Testicular tissue cryopreservation (TTC) is therefore offered to selected high‐risk patients as an experimental fertility‐preservation procedure that stores spe...

In vitro study and in silico reveal Teucrium Polium L. methanolic extract as an apoptosis inducer and a potential Bcl-2 inhibitor for breast cancer

Therapy of breast cancer (BC) overexpressing the pro-survival protein Bcl-2 remains a major clinical challenge. The discovery of natural anticancer drugs with potential as Bcl-2 inhibitors has generated increasing interest. The medicinal plant Teucrium polium L. (TPL) exhibits ph...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

An Operational Playbook for GCC Real-World Evidence Registries: From Framework to Field-Ready Practice

Paper 1 of the GCC RWE Operational Series (three-paper series). Across the Gulf Cooperation Council (GCC), a decade of health-data infrastructure investment is converging into a new regulatory reality: locally generated, registry-grade real-world evidence (RWE) is now required to...

An Operational Playbook for GCC Real-World Evidence Registries: From Framework to Field-Ready Practice

Paper 1 of the GCC RWE Operational Series (three-paper series). Across the Gulf Cooperation Council (GCC), a decade of health-data infrastructure investment is converging into a new regulatory reality: locally generated, registry-grade real-world evidence (RWE) is now required to...

A Study of Signalling Effectiveness in Entrepreneurial Opportunity Decisions

Signal effectiveness occurs when signals elicit the desired stakeholder validation, enabling entrepreneurs to gain confidence in opportunities, secure funding, and facilitate venture decision-making. Prior research has emphasised senders and signal attributes, but the receiver’s...

Targeting Overweight and Obesity Phenotypes for Secondary Prevention of Cardiovascular Disease: A Call to Action for the Middle East and Beyond

ABSTRACT Although there are conflicting clinical data on the efficacy of weight reduction in reducing secondary events in patients with comorbid overweight and obesity (OAO) and cardiovascular disease (CVD), there is excellent epidemiological and biological evidence of a cause–ef...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Baseline neutrophil count, benign ethnic neutropenia risk, and clozapine haematological monitoring: A multi-ethnic retrospective cohort study from the United Arab Emirates

Background Concerns about haematological toxicity and absolute neutrophil count (ANC) monitoring may limit clozapine use, particularly in multi-ethnic populations where benign ethnic neutropenia (BEN) and lower baseline ANC are common. We characterised baseline ANC distribution,...