Abterra Biosciences (United States)

Protein LanguageModel Decoys for Target Decoy Competitionin Proteomics: Quality Assessment and Benchmarks

Abstract Large-scale proteomics relies heavily on target–decoy competition for false discovery rate estimation in peptide identification, and the performance of this strategy depends strongly on the design of the decoy database. Classical generators such as reversal and shuffling...

OvercomingElectrochemiluminescence Immunoassay (ECLIA)Limitations: Conformation-Independent Quantitation of a TherapeuticAntibody by LC–MS/MS

Abstract Monoclonal antibody therapies have transformed cancer treatment by enabling targeted intervention even in advanced disease stages. However, reliable monitoring of circulating therapeutic antibody levels is critical to ensuring efficacy and patient safety. This study inve...