Aalborg University Hospital

Knowledge, attitudes, and practices about severe mental illness and willingness-to-pay for a new integrated care model across 6 European countries: a study protocol

Background People with Severe Mental Illness (SMI) experience a 15–20-year shorter life expectancy than the general population, with increased premature deaths from somatic illnesses, and twice to more than four times the general population’s all-cause mortality risk. Integrated...

Low‐level light therapy for dry eye disease and meibomian gland dysfunction: A systematic review and meta‐analysis

Abstract A healthy tear film is vital for ocular surface integrity and relies on the coordinated function of the lacrimal glands, meibomian glands and conjunctival goblet cells. Dysfunction in any of these elements can lead to dry eye disease (DED). This systematic review and met...

PD-1 and PD-L1 Expression in Inflammatory Bowel Disease: A Paired Immunohistochemical Study

Background/Objectives: The significance of the PD-1/PD-L1 immune checkpoint pathway in inflammatory bowel disease (IBD) is highlighted by side effects from checkpoint inhibitor therapies including autoimmune enterocolitis reminiscent of IBD. Methods: This exploratory study examin...

Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults.

Inborn errors of type I interferon (IFN-I) immunity account for ∼7-8% of herpes simplex encephalitis (HSE) cases in young children, but the pathogenesis of HSE in adults is largely unknown. We report that IFN-I autoantibodies (auto-Abs) in serum/plasma samples drawn before, durin...

Changes in skeletal muscle and physical function after cardiac surgery: a prospective study

Objectives To assess postoperative changes in muscle mass and quality, factors associated with these changes, and sarcopenia prevalence in older cardiac surgery patients. Design Secondary observational analysis of a randomized controlled early rehabilitation trial Setting Tertiar...

Demographic and clinical differences between individuals with and without DXA scans in Denmark

This study utilized two Danish registry-based cohorts to compare characteristics of DXA scanned individuals with not DXA scanned individuals. DXA scanned individuals had more comorbidities and used more medications, but there were signs of insufficient DXA scanning, particularly...

Operationalizing fear of cancer recurrence care: a modified Delphi study establishing a consensus-based clinical pathway for Danish cancer survivors

BACKGROUND AND PURPOSE: Fear of cancer recurrence (FCR) is a prevalent concern among cancer survivors. Although evidence-based FCR guidelines exist, their implementation requires further operationalization. This study aimed to establish expert consensus on a clinical pathway to o...

Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower‐risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo‐controlled trial

BACKGROUND: Vitamin C (VitC) is a cofactor for TET enzymes involved in DNA demethylation and epigenetic regulation. Mutations in TET2 are common drivers of leukemia. Preclinical studies suggest that VitC may delay leukemia progression. This study aimed to evaluate the biological...

How the nurse–patient relationship is enacted in Danish intensive care units: An ethnographic study of conscious mechanically ventilated patients

Introduction The nurse–patient relationship is crucial for conscious mechanically ventilated patients in the intensive care unit (ICU). While critical illness, immobilisation, and communication barriers challenge this relationship, the knowledge of its enactment in practice remai...

Phenotypic manifestations and variant reclassification of germline PTEN variants: a nationwide Danish study

Background Classification of heterozygous germline PTEN variants in patients with, or suspected of having, PTEN hamartoma tumour syndrome (PHTS) remains challenging. Accurate classification is essential as these patients require lifelong cancer surveillance. Methods We identified...

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

Penile cancer is a severe disease, and a large proportion is related to high-risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population-based data on the prevalence of p16 in penile cancer is scarce. We investigat...

Risk of bone metastases on [18F]NaF PET/CT in 734 patients with newly diagnosed prostate cancer

Abstract Purpose International guidelines recommend assessment for bone metastases in patients with high-risk prostate cancer (PC) and those with unfavourable intermediate-risk disease. These recommendations are largely based on studies using planar bone scintigraphy. We aimed to...

Locking plate fixation compared with tension-band wiring for patellar fractures: a multicentre randomized controlled trial

Aims Patellar fractures are associated with considerable postoperative morbidity, and tension-band wiring has high complication rates and suboptimal outcomes. Locking plate fixation is a recent surgical innovation which confers superior biomechanical stability. However, there is...

Regional Variation in ADHD Treatment and Diagnosis Among Children and Adolescents in Denmark

ABSTRACT Geographic variation in ADHD treatment and diagnosis among children and adolescents is well documented, yet the system‐level factors driving such differences remain poorly understood. We examined nationwide patterns of ADHD medication use and diagnoses in Denmark in 2024...

Durability of RSV Prefusion F Vaccine Protection across Two RSV Seasons

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death among older adults. Although first-season vaccine effectiveness against RSV-related hospitalization has been demonstrated for the bivalent RSV prefusion F protein-based vaccine (RSVpr...

Bivalent RSV Prefusion F Vaccine to Prevent Hospitalizations in Adults

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in adults, with the highest burden among older adults and individuals with chronic health conditions. The bivalent RSV prefusion F (RSVpreF) vaccine has been shown to prevent RSV-ass...

Selective Packaging of miR‐22 and miR‐29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis

ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicl...

Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis

BACKGROUND: In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clinical response-tailored antibiotic management strategy can shorten treat...

Lessons from the Danish Vascular (DanVasc) pilot survey: patient-reported outcomes following lower extremity, carotid and aortic artery disease

Patient-reported outcomes are insufficiently studied across the three predominant vascular diseases: lower extremity artery disease (LEAD), symptomatic carotid stenosis (SCS) and abdominal aortic aneurysm (AAA). To address this gap, the Danish Vascular (DanVasc) survey was develo...

The effect of telemonitoring on quality of life in people with insulin‐treated type 2 diabetes: A secondary analysis of a randomised controlled trial

Abstract Aims Telemonitoring in type 2 diabetes (T2D) care has demonstrated positive trends in terms of glycaemic control. However, evidence regarding its impact on patient‐reported outcomes, such as general and diabetes‐specific quality of life (QoL), remains inconclusive. In pa...