82th Hospital of Pla

Tumor-intrinsic SIRPα drives anti-PD-1 resistance in esophageal cancer by coordinating proliferative dominance and T-cell exhaustion: A target for combinatorial immunotherapy

Signal regulatory protein alpha (SIRPα) is a novel immune checkpoint protein. However, the role and mechanism of SIRPα in esophageal cancer (ESCA) remain unclear. This study explores the role of tumor intrinsic SIRPα in ESCA. Twenty-one ESCA samples treated or not with anti-progr...

Overcoming diagnostic pitfalls of Haemophilus influenzae type b frontal osteomyelitis: a systematic review plus index-case analysis in the post-vaccination era

Invasive Haemophilus influenzae type b (Hib) infections have become exceedingly rare in adults following universal childhood vaccination. This decline poses a diagnostic challenge, as clinical suspicion and laboratory protocols may not be optimized for its detection. To systemati...