81th Hospital of PLA

Phage-ICE tandems facilitate bacterial adaptation and antimicrobial resistance spread

Phages and integrative and conjugative elements (ICEs) drive bacterial evolution, but how their interplay shapes bacterial adaptation and antimicrobial resistance (AMR) dissemination remains unclear. Here, we characterize phage-ICE tandems formed by site-specific accretion of pha...

The miR‑339‑3p/CIZ1 axis is associated with LPS‑induced microglial injury and sevoflurane‑associated cognitive impairment in aged rats

Postoperative cognitive dysfunction (POCD) substantially impairs the quality of life in elderly patients, but its underlying molecular mechanisms remain largely elusive. This study aimed to investigate miR‑339‑3p expression and its functional role in LPS‑induced microglial injury...

Safety, feasibility, and palliative benefit of HIFU combined with PD-1 inhibitors for elderly patients with advanced pancreatic cancer: a real-world retrospective study

BACKGROUND: Pancreatic cancer remains largely refractory to immune checkpoint inhibitors. High-intensity focused ultrasound (HIFU) may modulate the immunosuppressive tumor microenvironment via immunogenic cell death, yet clinical evidence on HIFU combined with programmed cell dea...

MD-Mamba: A multi-scale dilated state-space network for breast cancer histopathology image classification

Background Automated breast histopathology classification requires models that can capture both local cellular morphology and broader tissue architecture while remaining computationally efficient. Methods We developed MD-Mamba, a multi-scale dilated state-space network with dual-...