174th hospital of the People's Liberation Army

Organelle contact sites as intracellular communication hubs linking metabolic stress to inflammatory disease

Abstract Membrane contact sites (MCSs) are specialized, non-fusogenic interfaces that allow organelles to exchange ions, lipids, metabolites and stress signals. These contacts support adaptation to nutrient, proteotoxic and inflammatory stress. However, persistent or misregulated...

miR-892b targeting CTNNB1 regulates sepsis-induced myocardial dysfunction

Numerous sepsis patients experience myocardial damage, leading to a high mortality rate of sepsis. To investigate the clinical and functional role of miR-892b in sepsis-induced myocardial dysfunction (SMD). The expression of miR-892b and CTNNB1 in clinical subjects was measured b...

Interplay of neuropeptide Y, metabolic dysfunction, and inflammation in cognitive impairment of major depressive disorder: a sex-stratified study

Abstract Background Major depressive disorder (MDD) is associated with metabolic disturbances (elevated TyG index), peripheral inflammation (IL-6, TNF-α, CRP), and cognitive deficits. Serum NPY levels vary by sex and reproductive aging, influencing appetite changes in MDD. Howeve...

Abdominal Acupuncture in Improving Allergic Rhinitis Through Estrogen Inhibition and Regulation of Immune Factor Secretion

Abstract Background Allergic rhinitis (AR) is a common allergic disease with limited treatment options and potential side effects from conventional therapies. This study aimed to investigate the therapeutic effects and underlying mechanisms of abdominal acupuncture (AA) on AR. Me...