Ziyan Shen

The effect of HIF-PHIs on anemia in non-dialysis-dependent CKD patients: a systematic review and network meta-analysis

This study compared the effects of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) and erythropoiesis-stimulating agents (ESAs) on anemia in non-dialysis-dependent chronic kidney disease (ND-CKD), with emphasis on follow-up duration and iron-metabolism markers....

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Abstract Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, i...