Ziwen Meng

MFG-E8 glycoprotein in inflammatory tissue regeneration: molecular mechanisms, therapeutic potential and advanced polymeric biomaterial delivery strategies

Milk fat globule epidermal growth factor 8 (MFG-E8) is a multifunctional glycoprotein that coordinates efferocytosis, inflammatory resolution, angiogenesis, and matrix remodeling during tissue repair. In ischemic and inflammatory microenvironments, endogenous MFG-E8 is functional...

Isoform Ratio Rather than Total Content Determines Nonlinear Bioactivity of Red Kidney Bean Phytohemagglutinin in Mice

Abstract Red kidney bean phytohemagglutinin (PHA) is an isolectin system of erythroagglutinating (PHA-E) and leucoagglutinating (PHA-L) subunits, but the biological significance of the natural ratio remains unclear. Here, natural PHA fractions with stepwise PHA-E/PHA-L ratios (N1...