Zihang Yin

DNA-Encoded Binding Affinity Shapes Robust CTCF Occupancy Across Cellular Contexts

CCCTC-binding factor (CTCF) is an architectural protein that organizes 3D genome architecture by binding to tens of thousands of genomic loci in a typical human cell type. Although DNA-binding affinity contributes to CTCF occupancy in vivo, the principles distinguishing robust fr...