Zhuolun Huyan

TsCl-Mediated, Copper-Catalyzed Deoxygenative Difluoromethoxylation Reaction of Quinoline- N -Oxides

Abstract Quinoline derivatives have played a pivotal role in the design and synthesis of drug-active substances and bioactive molecules for a long time. Herein, a TsCl-mediated, copper-catalyzed deoxygenative difluoromethoxylation reaction that facilitates the synthesis of 2-difl...