Zhun Liu

Pharmacological inhibition of PRKDC-mediated DNA damage response by 3-hydroxyflavone selectively alleviates MLL-rearranged acute myeloid leukemia

Abstract Rearrangements of the mixed lineage leukemia (MLL) gene in acute myeloid leukemia (AML) have been associated with resistance to chemotherapy, and there is currently an unmet clinical need for effective targeted therapies. In this study, we performed high-throughput drug...

Postoperative surveillance strategy in patients undergoing neoadjuvant chemoradiotherapy followed by curative resection for locally advanced rectal cancer

Abstract Background There are no consistent recommendations for postoperative surveillance intervals for rectal cancer in the major guidelines. Knowledge about recurrence hazards can help develop appropriate surveillance schedules. This study aimed to investigate transitions in r...