Zhu Shen

Candidate role of ADAMTS2 in regulating keratinocyte apoptosis via indirect NF-κB modulation in life-threatening PD-1 inhibitor-induced TEN-like cutaneous toxicity

Abstract Toxic epidermal necrolysis-like (TEN-like) immune-related cutaneous adverse event (ircAE) induced by programmed death 1 (PD-1) inhibitors is life-threatening; however, its pathogenesis remains unclear. This study aimed to dynamically characterize molecular signatures and...