Zhu Cao

TEFM-mediated regulation of mitochondrial function enhances CAR-T cell activity in ovarian cancer peritoneal metastasis

Chimeric antigen receptor (CAR)-T cell therapy in solid tumours is frequently limited by progressive functional impairment and inadequate metabolic fitness within the tumour microenvironment. Mitochondrial transcription elongation factor (TEFM) is an essential regulator of mitoch...