zhonghuo chen

H3K18 lactylation promotes Treg/Th17 imbalance via PTPRM-STAT3 axis in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits elevated lactate levels and Treg/Th17 imbalance, but underlying mechanisms remain unclear. We found that HCC patients show increased serum lactate correlated with expanded Tregs and reduced Th17 cells. Lactate treatment promoted FOXP3 while...