Zhizhan Ni

ENOPH1 orchestrates KRASG12D/G13D-driven glycolytic reprogramming and colorectal cancer progression through modulating the TGF-β/SMAD pathway

Oncogenic KRAS mutations (G12D/G13D) drive metabolic reprogramming in colorectal cancer (CRC), yet targetable downstream effectors remain poorly defined. Here, we identify enolase-phosphatase 1 (ENOPH1) as an essential transducer directly upregulated by the KRAS–MEK–ERK axis. ENO...