Zhiliang Fan

Engineering Klebsiella oxytoca for enhanced 2,3-butanediol production from gluconate

Abstract Background Historically, microbial production of 2,3-BD has relied predominantly on glucose as the substrate. However, its fermentation necessitates microaerobic conditions due to inherent redox imbalances. This limitation complicates process control and can lead to unde...

Engineering Thermothelomyces heterothallica for cellobionate production

Abstract In this study, a thermophilic cellulolytic filamentous fungus Thermothelomyces heterothallica was engineered for direct production of cellobionic acid (CBA) from alkali-pretreated wheat straw without the addition of external cellulases. The CBA bioproduction pathway was...