Zhilei Chen

Targeting Force-Regulated FimH Adhesin: Assays, Mannosides, and Biologics for Anti-Virulence Therapy of UPEC Infection

Abstract Urinary tract infections (UTIs) are among the most common bacterial infections, and recurrent UTIs caused by uropathogenic Escherichia coli (UPEC) drive antibiotic use and antimicrobial resistance. FimH, the mannose-binding adhesin at the tip of type 1 pili, is a central...