Zhijie Li

Synthetic lethal screens reveal p300/CBP as a vulnerability for GNAQ-driven uveal melanomas

Abstract Uveal melanoma is the most common intraocular cancer in adults, driven by activating mutations in GNAQ or GNA11 , which encode the G proteins Gαq and Gα11. Currently, therapeutic options for uveal melanoma, particularly metastatic uveal melanoma, remain limited. Through...

Automated Multimodal Correlative Registration for Organelle-Specific Elemental and Isotopic Imaging

Abstract Mapping the subcellular partitioning of therapeutics is important for understanding their trafficking, mechanisms of action, and off-target effects. NanoSIMS provides chemical images of labeled therapeutics, but assigning these signals to cellular structures requires cor...

Chlorambucil-LoadedNanomicelles against HepatocellularCarcinoma

Abstract For hepatocellular carcinoma (HCC) therapy, an NQO1-responsive chlorambucil-loaded nanomicelle (CLB-AZO-mPEG5) was designed and synthesized to overcome the poor water solubility of chlorambucil and to explore its mechanism against HCC. CLB-AZO-mPEG5 was constructed by co...