Zhihui Wei

Xanthatin directly targets ZDHHC7 to inhibit NLRP3 palmitoylation and inflammasome activation, alleviating sepsis and acute lung injury

Aberrant activation of the NLRP3 inflammasome drives the pathogenesis of diverse inflammatory diseases, including acute respiratory distress syndrome (ARDS) and sepsis. Among the post-translational modifications regulating NLRP3, S-palmitoylation contributes to NLRP3 localization...