Zhihui Huang

A hypoxia/necrosis-driven metabolic-epigenetic axis H3K9 lactylation-mediated SKP2 signaling promotes glioblastoma progression

Abstract Tumor hypoxia/necrosis as a hallmark of glioblastoma (GBM) is strongly associated with malignant progression and poor prognosis of GBM, however, its roles and mechanisms in the behaviors of neighboring surviving GBM cells remain poorly understood. Here, we analyzed publi...