Zhihong Li

Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design

PD-1/PD-L1 blockade can produce durable tumor control, yet primary, adaptive, and acquired resistance remain common. Existing accounts often catalogue resistance by cellular compartment, obscuring the coordinated nature of tumor adaptation. Here, we introduce immune-pressure redi...

Alternative polyadenylation in cancer: mechanisms, functions, and therapeutic potential

Alternative polyadenylation (APA) is a pervasive post-transcriptional regulatory mechanism that generates transcript isoforms with distinct 3′ untranslated regions, terminal exons, or coding potential, thereby influencing mRNA stability, translation, localization, and protein out...