Zhihao Qiang

Recurrent reversible mutations at gaf1 driving metastable TORC1 inhibitor resistance in fission yeast

ABSTRACT Metastable phenotypic inheritance is often attributed to epigenetic mechanisms, but reversible genetic alterations can produce similar instability. Here, we investigated the basis of unstable resistance to TORC1 inhibitor (rapamycin plus caffeine) in Schizosaccharomyces...