Zhihao Chen

MACF1 condensates serve as molecular rheostats translating mechanical stress into bone adaptation

Bone dynamically maintains homeostasis through mechanotransduction, a process essential for skeletal integrity and frequently disrupted in disease. Yet how bone cells decode mechanical cues into adaptive responses remains poorly understood. Here, we identify MACF1, a cytoskeletal...

Salidroside ameliorates glucocorticoid-induced osteoporosis by regulating the PI3K/Akt/mTOR pathway: a network pharmacology and in vivo

Osteoporosis (OP) is a bone disorder, common cause of bone fracture and disability. Management of it needs development of an alternative medicine and present report evaluates the protective effect of salidroside against glucocorticoid induced osteoporosis in rat model. Network ph...