Zhi Li

Preclinical and First‐In‐Human Evaluation of Ribupatide ( HRS9531 ), a Dual GLP ‐1/ GIP Receptor Agonist

ABSTRACT Aims This study assessed the preclinical and clinical pharmacokinetics (PK), pharmacodynamics (PD), safety and tolerability of ribupatide (HRS9531), a novel dual agonist of glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptors....

Aging-Induced Additive Release and Degradation Mechanisms in Recycled Polyvinyl Chloride: Coupling Experimental and Molecular Dynamics Insights

Abstract The global accumulation of plastic waste has driven the widespread adoption of recycling strategies for sustainable resource management. However, uncertainties in recycled material quality and the release of plastic additives remain critical challenges for environmental...

Why Does a Shallow Land Model Underestimate the Dryland Drying Trends?

Abstract Most land surface models (LSMs) and macroscale hydrological models with shallow soil profiles underestimate observed terrestrial water storage (TWS) declines across global drylands. Here, we incorporated a recently developed global data set of depth to bedrock with spati...