Zhenzi Zhang-yan

Oral Nano-Oxygen Modulates the Intestinal HIF-2α/NEU3/Ceramide Axis to Mitigate NAFLD

Abstract The intestinal hypoxia-inducible factor-2α (HIF-2α)/neuraminidase 3 (NEU3)/ceramide axis has emerged as an important regulator of gut–liver communication in nonalcoholic fatty liver disease (NAFLD). However, systemic inhibition of HIF-2α may interfere with hepatic glucos...