Zhenzhen Wu

Differential regulation of basal and interferon-induced APOL1 gene expression in podocytes

APOL1 genetic variants associated with kidney disease become pathogenic when APOL1 gene expression is induced to high levels, however, the mechanism of APOL1 gene regulation is not well characterized. Using human podocyte cell lines, the induction of APOL1 gene expression from va...

Integrated single-cell and functional analyses define fatty acid oxidation activation associates with poor prognosis in oral squamous cell carcinoma

<title>Abstract</title> Fatty acid oxidation (FAO) activation was reported to promote tumor progression, yet its role in oral squamous cell carcinoma (OSCC) remains incompletely understood. Here, we found that FAO was significantly activated in both OSCC tissue biopsies and OSCC...