Zhenyu Bi

Oxalate induces phosphatidylserine externalization, apoptosis, and crystal-cell adhesion in renal tubular epithelial cells through the ROS-ADAM17-Notch1 axis

Abstract Background Oxalate salts induce reactive oxygen species (ROS) generation, leading to phosphatidylserine (PS) externalization from renal tubule epithelial cells and the development of kidney stone. This research investigated the roles of ADAM17 (A Disintegrin and Metallop...