Zhenya Wang

Lactylation-regulated METTL3-mediated cholesterol metabolic reprogramming via FDFT1 facilitates macrophage polarization in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits limited clinical response to immunotherapy, highlighting the pressing need for novel strategies targeting its immunosuppressive microenvironment. While metabolic reprogramming and epigenetic alterations contribute to malignancy, the role of...

USP10 mitigates Ang II–induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1

Atrial fibrillation (AF) contributes to cardiovascular morbidity and mortality. Ubiquitin-specific peptidase 10 (USP10) plays a crucial role in numerous cellular processes; however, its particular role in AF remains largely unexplored. In the present study, USP10 expression was a...