Zhenhua Ren

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...