Zhenhao Fei

Ellagic Acid Enhances RSL3 ‐Induced Ferroptosis by Inhibiting the Nrf2/ HO ‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) exhibits profound therapeutic resistance due to redox adaptation, particularly through Nrf2/HO-1 pathway activation. Ferroptosis induction via GPX4 inhibitors (e.g., RSL3) is promising but limited by adaptive antioxidant responses. Ellagic...