Zhengshan Chen

Single-Cell BCR and Transcriptome Analysis Revealed Potent Neutralizing Antibodies in Response to HAdV-4 Infection

Human adenovirus type 4 (HAdV-4) is a predominant serotype causing acute respiratory infections, for which no antibody drugs have been clinically approved to date, resulting in an urgent unmet medical need. This study aimed to identify highly potent neutralizing antibodies by dis...

An engineered AAV variant with high-efficiency outer retinal tropism for gene delivery

Retinal degenerative diseases, such as Stargardt disease and age-related macular degeneration (AMD), are leading causes of irreversible blindness, and AAV-based gene therapy has become a key therapeutic option. For most natural AAV serotypes, however, efficient transduction of th...