Zhengda Li

CYP2S1: a novel regulator of PMN-MDSC recruitment and immunotherapy resistance in esophageal squamous cell carcinoma

Chemoimmunotherapy resistance significantly limits the clinical management of esophageal squamous cell carcinoma (ESCC). To identify tumor-intrinsic regulators associated with an immunosuppressive tumor microenvironment (TME) and treatment failure, we integrated proteomic profili...

Single-blastomere next-generation sequencing confirms chromosomal abnormalities as the primary cause of impaired developmental potential in embryos with abnormal cleavage patterns

Abnormal cleavage impairs embryonic development, but the effects of different abnormal cleavage patterns and occurrence stages remain unclear. Previous chromosomal analyses at the blastocyst stage have failed to elucidate the underlying mechanism. This study investigated the effe...