Zheng Pan

Hepatocyte Hedgehog activation attenuates acetaminophen-induced liver injury through a Vegfa-associated vascular response

Abstract Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure, yet early pathways linking hepatocellular stress to tissue integrity remain incompletely defined. Here, we demonstrate that canonical Hh signaling is rapidly activated in centrilobula...